Binance.US
Binance offers the lowest trading fees of any exchange. Coinbase charges buyers 0.60% but Binance only charges a 0.075% fee, making Coinbase's fees 8x higher than Binance.US.
Binance also allows users to buy BNB coin, the 3rd most valuable cryptocurrency in the world (excluding USDC and USDT). BNB powers the Binance Smart Chain (BSC) which is possibly the best blockchain for Decentralized Finance (DeFi).
In my opinion, the best way for American investors to get involved in DeFi is to open a Binance.US account, buy some BNB, then transfer that BNB to a hardware wallet like a Ledger Nano ($59).
Why do DeFi users need the security of a hardware wallet? Check out my article on what I wish I'd done before diving into DeFi.